Tuberous Sclerosis with Severe Cutaneous Manifestation and Multiples Facial Angiofibromas

• Published in: Head & neck pathology (Totowa, N.J.) Vol. 10; no. 4; pp. 542 - 546
• Main Authors: Garcia, Natália Galvão, de Carli, Marina Lara, Oliveira, Denise Tostes, Soares, Cléverson Teixeira, Ribeiro Júnior, Noé Vital, Sperandio, Felipe Fornias, Hanemann, João Adolfo Costa
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2016
• Subjects: Angiofibroma - etiology; Angiofibroma - pathology; Case Report; Dentistry; Face - pathology; Humans; Male; Medicine; Medicine & Public Health; Oral and Maxillofacial Surgery; Otorhinolaryngology; Pathology; Skin Neoplasms - etiology; Skin Neoplasms - pathology; Tuberous Sclerosis - complications; Tuberous Sclerosis - pathology; Young Adult; Tuberous sclerosis; Critical features; Cutaneous manifestations
• ISSN: 1936-055X; 1936-0568
• DOI: 10.1007/s12105-016-0723-8

Tuberous sclerosis is an extremely variable disease that can affect virtually any organ in the body. The most common findings are cutaneous manifestations, that are critical features in helping to establish diagnosis. We present a case of young man with diagnosis of tuberous sclerosis presenting multiple shagreen patches around the trunk, in the neck and genital region; large plaques with uneven surfaces on the right side of the lower back; and multiple papular lesions in his face, particularly around the nasolabial region, eyebrows and forehead. Considering that tuberous sclerosis is a disease with a highly variable clinical presentation, thus dentists and doctors should be aware of the different manifestations that may be found.