Research progress on the relationship between autophagy and chronic complications of diabetes

Diabetes is a common metabolic disease whose hyperglycemic state can induce diverse complications and even threaten human health and life security. Currently, the treatment of diabetes is restricted to drugs that regulate blood glucose and have certain accompanying side effects. Autophagy, a researc...

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Published inFrontiers in physiology Vol. 13; p. 956344
Main Authors Ge, Xia, Wang, Ling, Fei, Aihua, Ye, Shandong, Zhang, Qingping
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 08.08.2022
Subjects
autophagy
chronic complications
diabetes drug
molecular mechanism
Physiology
regulation
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Summary:Diabetes is a common metabolic disease whose hyperglycemic state can induce diverse complications and even threaten human health and life security. Currently, the treatment of diabetes is restricted to drugs that regulate blood glucose and have certain accompanying side effects. Autophagy, a research hotspot, has been proven to be involved in the occurrence and progression of the chronic complications of diabetes. Autophagy, as an essential organismal defense mechanism, refers to the wrapping of cytoplasmic proteins, broken organelles or pathogens by vesicles, which are then degraded by lysosomes to maintain the stability of the intracellular environment. Here, we review the relevant aspects of autophagy and the molecular mechanisms of autophagy in diabetic chronic complications, and further analyze the impact of improving autophagy on diabetic chronic complications, which will contribute to a new direction for further prevention and treatment of diabetic chronic complications.
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Edited by: Jie Yang, Xinqiao Hospital, China
Reviewed by: Esma Nur Okatan, University of Istinye, Turkey
Puneet Khandelwal, The Johns Hopkins Hospital, United States
This article was submitted to Cell Physiology, a section of the journal Frontiers in Physiology
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2022.956344