Single-cell transcriptomic analysis of the tumor ecosystem of adenoid cystic carcinoma

• Published in: Frontiers in oncology Vol. 12; p. 1063477
• Main Authors: Lin, Quanquan, Fang, Zhanjie, Sun, Jinlong, Chen, Fei, Ren, Yipeng, Fu, Zhenhong, Yang, Sefei, Feng, Lin, Wang, Feng, Song, Zhigang, Chen, Wei, Yu, Wenjun, Wang, Chen, Shi, Yixin, Liang, Yue, Zhang, Haizhong, Qu, Hongzhu, Fang, Xiangdong, Xi, Qing
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 17.11.2022
• Subjects: adenoid cystic carcinoma; EN1; head and neck cancer; MYB; Oncology; single-cell transcriptomic analysis

Adenoid cystic carcinoma (ACC) is a malignant tumor that originates from exocrine gland epithelial cells. We profiled the transcriptomes of 49,948 cells from paracarcinoma and carcinoma tissues of three patients using single-cell RNA sequencing. Three main types of the epithelial cells were identifi...