Existence of Functional Connectome Fingerprint during Infancy and Its Stability over Months

• Published in: The Journal of neuroscience Vol. 42; no. 3; pp. 377 - 389
• Main Authors: Hu, Dan, Wang, Fan, Zhang, Han, Wu, Zhengwang, Zhou, Zhen, Li, Guoshi, Wang, Li, Lin, Weili, Li, Gang
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 19.01.2022
• Subjects: Adolescents; Adults; Brain; Brain - diagnostic imaging; Brain Mapping; Child, Preschool; Children; Cognitive ability; Connectome; Female; Fingerprinting; Fingerprints; Functional magnetic resonance imaging; Functional Neuroimaging; Humans; Infant; Infant, Newborn; Infants; Magnetic Resonance Imaging; Male; Nerve Net - diagnostic imaging; Networks; Neural networks; Phenotypes; Stability; Structure-function relationships; resting-state MRI; functional connectome fingerprint; cognition; infant; functional connectome
• ISSN: 0270-6474; 1529-2401
• DOI: 10.1523/JNEUROSCI.0480-21.2021

The functional connectome fingerprint is a cluster of individualized brain functional connectivity patterns that are capable of distinguishing one individual from others. Although its existence has been demonstrated in adolescents and adults, whether such individualized patterns exist during infancy is barely investigated despite its importance in identifying the origin of the intrinsic connectome patterns that potentially mirror distinct behavioral phenotypes. To fill this knowledge gap, capitalizing on a longitudinal high-resolution structural and resting-state functional MRI dataset with 104 human infants (53 females) with 806 longitudinal scans (age, 16-876 d) and infant-specific functional parcellation maps, we observe that the brain functional connectome fingerprint may exist since infancy and keeps stable over months during early brain development. Specifically, we achieve an ∼78% individual identification rate by using ∼5% selected functional connections, compared with the best identification rate of 60% without connection selection. The frontoparietal networks recognized as the most contributive networks in adult functional connectome fingerprinting retain their superiority in infants despite being widely acknowledged as rapidly developing systems during childhood. The existence and stability of the functional connectome fingerprint are further validated on adjacent age groups. Moreover, we show that the infant frontoparietal networks can reach similar accuracy in predicting individual early learning composite scores as the whole-brain connectome, again resembling the observations in adults and highlighting the relevance of functional connectome fingerprint to cognitive performance. For the first time, these results suggest that each individual may retain a unique and stable marker of functional connectome during early brain development. Functional connectome fingerprinting during infancy featuring rapid brain development remains almost uninvestigated even though it is essential for understanding the early individual-level intrinsic pattern of functional organization and its relationship with distinct behavioral phenotypes. With an infant-tailored functional connection selection and validation strategy, we strive to provide the delineation of the infant functional connectome fingerprint by examining its existence, stability, and relationship with early cognitive performance. We observe that the brain functional connectome fingerprint may exist since early infancy and remains stable over months during the first 2 years. The identified key contributive functional connections and networks for fingerprinting are also verified to be highly predictive for cognitive score prediction, which reveals the association between infant connectome fingerprint and cognitive performance.