Nanocarriers: A novel strategy for the delivery of CRISPR/Cas systems

In recent decades, clustered regularly interspaced short palindromic repeat/CRISPR-associated protein (CRISPR/Cas) has become one of the most promising genome-editing tools for therapeutic purposes in biomedical and medical applications. Although the CRISPR/Cas system has truly revolutionized the er...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in chemistry Vol. 10; p. 957572
Main Authors Hejabi, Faranak, Abbaszadeh, Mohammad Sadegh, Taji, Shirinsadat, O’Neill, Andrew, Farjadian, Fatemeh, Doroudian, Mohammad
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 26.07.2022
Subjects
Chemistry
CRISPR/Cas9
gene therapy
nanocarriers
nanomedicine
non-viral vector
Online AccessGet full text

Cover

More Information
Summary:In recent decades, clustered regularly interspaced short palindromic repeat/CRISPR-associated protein (CRISPR/Cas) has become one of the most promising genome-editing tools for therapeutic purposes in biomedical and medical applications. Although the CRISPR/Cas system has truly revolutionized the era of genome editing, the safe and effective delivery of CRISPR/Cas systems represents a substantial challenge that must be tackled to enable the next generation of genetic therapies. In addition, there are some challenges in the in vivo delivery to the targeted cells/tissues. Nanotechnology-based drug delivery systems can be employed to overcome this issue. This review discusses different types and forms of CRISPR/Cas systems and the current CRISPR/Cas delivery systems, including non-viral carriers such as liposomes, polymeric, and gold particles. The focus then turns to the viral nanocarriers which have been recently used as a nanocarrier for CRISPR/Cas delivery.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Reviewed by: Lin Li, Northwestern Polytechnical University, China
Jianhua Zou, National University of Singapore, Singapore
Edited by: Ahmad Gholami, Shiraz University of Medical Sciences, Iran
These authors have contributed equally to this work
This article was submitted to Nanoscience, a section of the journal Frontiers in Chemistry
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2022.957572