Effects of apamin on memory processing of hippocampal-lesioned mice

• Published in: European journal of pharmacology Vol. 382; no. 3; pp. 151 - 156
• Main Authors: Ikonen, Sami, Riekkinen, Paavo
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.10.1999; Elsevier
• Subjects: Animals; Apamin; Apamin - pharmacology; Biological and medical sciences; Calcium - physiology; Dose-Response Relationship, Drug; Female; Hippocampus; Hippocampus - physiology; K + channel, Ca 2+-dependent; Learning; Maze Learning - drug effects; Medical sciences; Memory; Memory - drug effects; Memory - physiology; Mice; Mice, Inbred C57BL; Mouse; Neuropharmacology; Neuroprotective agent; Pharmacology. Drug treatments; Potassium Channel Blockers; Spatial navigation; Time Factors; Learning; Apamin; Mouse; Memory; Spatial navigation; K + channel, Ca 2+-dependent; Hippocampus; Hippocampectomy; Intraperitoneal administration; Acute; Rodentia; Calcium antagonist; Neuroprotective agent; Biological activity; Cerebral disorder; Vertebrata; Mammalia; Acquisition process; Animal; Central nervous system disease; Working memory; Spatial memory
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/S0014-2999(99)00616-0

We investigated the effects of acute i.p. injections of the Ca 2+-dependent K + channel blocker, apamin, on water maze spatial navigation and radial arm maze performance in mice with partial hippocampal-lesions. In the radial arm maze, apamin 0.06 and 0.2 mg/kg dose-dependently reversed the lesion-induced defect. In the water maze, apamin 0.2 mg/kg alleviated the defect, but a lower dose 0.06 mg/kg was ineffective. At a higher dose, 0.4 mg/kg, apamin impaired the water maze performance. These results suggest that Ca 2+-dependent K + channel blockers can alleviate the spatial reference memory and working memory impairment induced by partial hippocampal lesions.