The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma

N6-methyladenosine (m6A) RNA methylation is an epigenetic modification that has emerged in the last few years and has received increasing attention as the most abundant internal RNA modification in eukaryotic cells. m6A modifications affect multiple aspects of RNA metabolism, and m6A methylation has...

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Published inFrontiers in immunology Vol. 13; p. 917153
Main Authors Chen, Fan, Xie, Xuan, Chao, Min, Cao, Haiyan, Wang, Liang
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 30.05.2022
Subjects
cancer progression
GBM
Immunology
immunotherapy
m6A
stem cells
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Summary:N6-methyladenosine (m6A) RNA methylation is an epigenetic modification that has emerged in the last few years and has received increasing attention as the most abundant internal RNA modification in eukaryotic cells. m6A modifications affect multiple aspects of RNA metabolism, and m6A methylation has been shown to play a critical role in the progression of multiple cancers through a variety of mechanisms. This review summarizes the mechanisms by which m6A RNA methylation induced peripheral cancer cell progression and its potential role in the infiltration of immune cell of the glioblastoma microenvironment and novel immunotherapy. Assessing the pattern of m6A modification in glioblastoma will contribute to improving our understanding of microenvironmental infiltration and novel immunotherapies, and help in developing immunotherapeutic strategies.
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Reviewed by: Kenan Zhang, Capital Medical University, China; Jun Dong, Second Affiliated Hospital of Soochow University, China
Edited by: Chunsheng Kang, Tianjin Medical University General Hospital, China
This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.917153