Association of toll-like receptors polymorphisms with COPD risk in Chinese population

• Published in: Frontiers in genetics Vol. 13; p. 955810
• Main Authors: Sun, Shulei, Shen, Yuehao, Feng, Jing
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 26.10.2022
• Subjects: chronic obstructive pulmonary disease; Genetics; polymorphisms; TLR2; TLR3; TLR9; toll-like receptors
• ISSN: 1664-8021; 1664-8021
• DOI: 10.3389/fgene.2022.955810

Background: Previous studies have reported that the Toll-like receptors (TLRs) are related with the progress of chronic obstructive pulmonary disease (COPD). We aimed to explore the association of TLRs single nucleotide polymorphisms (SNPs) and COPD risk. Methods: 170 COPD patients and 181 healthy controls were enrolled in this case-control study. MassARRAY platform was used for genotyping seven tagging SNPs ( TLR2 : rs3804100, rs4696480, rs3804099; TLR3 : rs3775290, rs3775291, rs5743305; TLR9 : rs352140) of TLRs. The correlations between the SNPs and COPD risk were determined using logistic regression. Results: We found that the rs3775291 of TLR3 significant decreased the risk of COPD (TT versus CC: non-adjusted OR = 0.329, 95% CI = 0.123–0.879, p = 0.027). In the genetic models analysis, the rs3775291 was associated with a decreased effect of COPD based on the recessive model (TT versus CC/CT: non-adjusted OR = 0.377, 95% CI = 0.144–0.988  p = 0.047). The rs4696480 of TLR2 gene was associated with a decreased risk of COPD after adjustment by age and gender (TA versus AA: adjusted OR = 0.606, 95% CI = 0.376–0.975, p = 0.039). Conclusion: Our study showed that genetic variants in TLRs were associated with risk of COPD. The rs3775291 and rs4696480 may act as a potential biomarker for predicting the risk of COPD in Chinese population.