Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing

• Published in: Frontiers in neuroscience Vol. 16; p. 935371
• Main Authors: Xia, Li, Ripley, Sara, Jiang, Zhenhua, Yin, Xue, Yu, Zhiping, Aiken, Steve J., Wang, Jian
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 06.07.2022
• Subjects: cochlear efferent; coding-in-noise deficit; fluctuation profile; Guinea pigs; Neuroscience; noise-induced synaptopathy; temporal processing

Noise induced synaptopathy (NIS) has been researched extensively since a large amount of synaptic loss without permanent threshold shift (PTS) was found in CBA mice after a brief noise exposure. However, efforts to translate these results to humans have met with little success—and might not be possi...