Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing

Noise induced synaptopathy (NIS) has been researched extensively since a large amount of synaptic loss without permanent threshold shift (PTS) was found in CBA mice after a brief noise exposure. However, efforts to translate these results to humans have met with little success—and might not be possi...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in neuroscience Vol. 16; p. 935371
Main Authors Xia, Li, Ripley, Sara, Jiang, Zhenhua, Yin, Xue, Yu, Zhiping, Aiken, Steve J., Wang, Jian
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 06.07.2022
Subjects
cochlear efferent
coding-in-noise deficit
fluctuation profile
Guinea pigs
Neuroscience
noise-induced synaptopathy
temporal processing
Online AccessGet full text

Cover

More Information
Summary:Noise induced synaptopathy (NIS) has been researched extensively since a large amount of synaptic loss without permanent threshold shift (PTS) was found in CBA mice after a brief noise exposure. However, efforts to translate these results to humans have met with little success—and might not be possible since noise exposure used in laboratory animals is generally different from what is experienced by human subjects in real life. An additional problem is a lack of morphological data and reliable functional methods to quantify loss of afferent synapses in humans. Based on evidence for disproportionate synaptic loss for auditory nerve fibers (ANFs) with low spontaneous rates (LSR), coding-in-noise deficits (CIND) have been speculated to be the major difficulty associated with NIS without PTS. However, no robust evidence for this is available in humans or animals. This has led to a re-examination of the role of LSR ANFs in signal coding in high-level noise. The fluctuation profile model has been proposed to support a role for high-SR ANFs in the coding of high-level noise in combination with efferent control of cochlear gain. This study aimed to induce NIS by a low-level, intermittent noise exposure mimicking what is experienced in human life and examined the impact of the NIS on temporal processing under masking. It also evaluated the role of temporal fluctuation in evoking efferent feedback and the effects of NIS on this feedback.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Reviewed by: Alexander Galazyuk, Northeast Ohio Medical University, United States; Mariano Nicolás Di Guilmi, CONICET Instituto de Investigaciones en Ingeniería Genética y Biología Molecular Dr. Héctor N. Torres (INGEBI), Argentina
This article was submitted to Auditory Cognitive Neuroscience, a section of the journal Frontiers in Neuroscience
These authors have contributed equally to this work
Edited by: Wei Qiu, State University of New York, Plattsburgh, United States
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2022.935371