Minimal within-day variation of high density lipoprotein cholesterol and apolipoprotein A-I levels in normal subjects

Blood was drawn from twenty normal hospital employees after a 12-14 hr fast (9:30 AM), and at 4 hr (1:30 PM) and 7 hr (4:30 PM) thereafter while test subjects consumed their habitual diet. Absorptive chylomicronemia was reflected in average triglyceride increases of 30% and 53% at 4 hr and 7 hr, res...

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Published inJournal of lipid research Vol. 21; no. 7; pp. 953 - 955
Main Authors Henderson, L O, Saritelli, A L, LaGarde, E, Herbert, P N, Shulman, R S
Format Journal Article
LanguageEnglish
Published United States Elsevier 01.09.1980
Subjects
Apolipoprotein A-I
Apolipoproteins - blood
Cholesterol - blood
Chylomicrons - blood
Circadian Rhythm
Humans
Lipoproteins, HDL - blood
Triglycerides - blood
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Summary:Blood was drawn from twenty normal hospital employees after a 12-14 hr fast (9:30 AM), and at 4 hr (1:30 PM) and 7 hr (4:30 PM) thereafter while test subjects consumed their habitual diet. Absorptive chylomicronemia was reflected in average triglyceride increases of 30% and 53% at 4 hr and 7 hr, respectively. No significant changes in total (< 1%) and high density lipoprotein (< 0.1%) cholesterol concentrations were observed. Moreover, levels of the major high density lipoprotein apolipoprotein, apoA-I, varied by less than 3%. Blood samples, randomly obtained during standard working hours, appear adequate for quantitation of high density lipoprotein cholesterol and apolipoprotein A-I levels.
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ISSN:0022-2275
DOI:10.1016/S0022-2275(20)34793-3