Elevated body mass in National Football League players linked to cognitive impairment and decreased prefrontal cortex and temporal pole activity

• Published in: Translational psychiatry Vol. 2; no. 1; p. e68
• Main Authors: Willeumier, K, Taylor, D V, Amen, D G
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2012; Nature Publishing Group
• Subjects: 631/378/1457/1945; 692/699/2743/393; 692/699/476; 692/700/1421/1846/2771; Adult; Aged; Behavioral Sciences; Biological Psychology; Body Height; Body Mass Index; Brain Concussion - physiopathology; Brain Injury, Chronic - physiopathology; Cognition Disorders - physiopathology; Football; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Multimodal Imaging; Neurosciences; Obesity - physiopathology; Original; original-article; Overweight - physiopathology; Pharmacotherapy; Positron-Emission Tomography; Prefrontal Cortex - blood supply; Psychiatry; Regional Blood Flow - physiology; Temporal Lobe - blood supply; Tomography, X-Ray Computed; Waist Circumference; waist-to-height ratio (WHtR); cognition; single photon computed tomography (SPECT); prefrontal cortex; temporal pole; body mass index (BMI)
• ISSN: 2158-3188; 2158-3188
• DOI: 10.1038/tp.2011.67

Obesity is a risk factor for neurodegenerative disease and has been shown to adversely affect cognitive function. Professional athletes who participate in sports, which expose them to repetitive concussions, may be at heightened risk for cognitive impairment. Here, we investigated the effects of body mass as measured by waist-to-height ratio (WHtR) on regional cerebral blood flow using single-photon emission computed tomography imaging in 38 healthy weight (WHtR mean 49.34±2.8; age 58±9.6) and 38 overweight (WHtR mean 58.7±4.7; age 58±13.3) retired National Football League football players. After matching for age and position, we used a two sample t -test to determine the differences in blood flow in healthy versus overweight subjects. Statistical parametric mapping revealed a higher WHtR ratio is associated with decreased blood flow in Brodmann areas 8, 9 and 10, brain regions involved in attention, reasoning and executive function ( P <0.05, family-wise error) along with deficits in the temporal pole. Moreover, overweight athletes had significant decrease in attention ( P =0.01326), general cognitive proficiency ( P =0.012; Microcog: Assessment of Cognitive Functioning) and memory ( P =0.005; Mild Cognitive Impairment Screen). The association between elevated WHtR percentage and decreased blood flow in the prefrontal cortex and temporal pole may be correlated with the decreased performance on tests of attention and memory. These findings suggest that a weight management program may be critical to the health of athletes who have been exposed to mild brain trauma during their careers.