Immunological response to quadrivalent HPV vaccine in treatment of recurrent respiratory papillomatosis

• Published in: European archives of oto-rhino-laryngology Vol. 273; no. 10; pp. 3231 - 3236
• Main Authors: Tjon Pian Gi, Robin E. A., San Giorgi, Michel R. M., Pawlita, Michael, Michel, Angelika, van Hemel, Bettien M., Schuuring, Ed M. D., van den Heuvel, Edwin R., van der Laan, Bernard F. A. M., Dikkers, Frederik G.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2016
• Subjects: Adult; Antibodies, Viral - blood; Female; Head and Neck Surgery; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 - therapeutic use; Humans; Laryngology; Male; Medicine; Medicine & Public Health; Neurosurgery; Otorhinolaryngology; Papillomaviridae - immunology; Papillomavirus Infections - prevention & control; Papillomavirus Infections - surgery; Regression Analysis; Respiratory Tract Infections - prevention & control; Respiratory Tract Infections - surgery; Retrospective Studies; Therapeutic drug; Vaccine; Recurrent respiratory papillomatosis; Immunology
• ISSN: 0937-4477; 1434-4726
• DOI: 10.1007/s00405-016-4085-3

Aim of this study was to explore influence of the quadrivalent HPV vaccine (Gardasil ® ) on the immune status of recurrent respiratory papillomatosis (RRP) patients. In retrospective observational study, six RRP patients who received the quadrivalent HPV vaccine and whose HPV seroreactivity was measured were included. Multiplex HPV Serology was used to determine HPV-specific antibodies pre- and post-vaccination. Surgical interventions and patient records were analyzed. Five HPV6 and 1 HPV11 infected patient were included. Mean antibody reactivity against the associated HPV type rose from 1125 median fluorescence intensity (MFI) pre-vaccination to 4690 MFI post-vaccination ( p  < 0.001). Median post-vaccination follow-up was 4 years. Poisson regression analysis showed that the quadrivalent HPV vaccine decreased the incidence rate of surgeries. The immune system of RRP patients is able to increase antibody reactivity against the associated HPV type. A double blind randomized controlled trial is needed to determine whether this immunological increase can cause decrease in number of surgeries.