Evaluation of Lp-PLA2 mass, vitronectin and PAI-1 activity levels in patients with preeclampsia

• Published in: Archives of gynecology and obstetrics Vol. 292; no. 1; pp. 53 - 58
• Main Authors: Balcı Ekmekçi, Özlem, Ekmekçi, Hakan, Güngör, Zeynep, Tüten, Abdullah, Toprak, M. Sait, Korkmaz, Meltem, Öncül, Mahmut, Çalışkan, Oktay, Kucur, Mine, Donma, Orkide, Madazlı, Rıza, Sönmez, Hüseyin
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2015; Springer Nature B.V
• Subjects: 1-Alkyl-2-acetylglycerophosphocholine Esterase - blood; Adult; C-Reactive Protein - metabolism; Case-Control Studies; Endocrinology; Enzyme-Linked Immunosorbent Assay; Female; Gynecology; Human Genetics; Humans; Maternal-Fetal Medicine; Medicine; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Plasminogen Activator Inhibitor 1 - metabolism; Pre-Eclampsia - blood; Preeclampsia; Pregnancy; Tissue Plasminogen Activator - blood; Vitronectin - blood; Young Adult; Endothelial dysfunction; PAI-1; Vitronectin; T-PA; Preeclampsia; Lp-PLA2
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-014-3601-1

Purpose The aim of the current study is to determine, correlate and compare the plasma lipoprotein-associated phospholipase A2 (Lp-PLA2), vitronectin (Vn), Plasminogen activator inhibitor-1 (PAI-1) activity and tissue plasminogen activator (t-PA) levels in early-onset preeclampsia, late-onset preeclampsia and in control pregnant women. Methods A total of 79 individuals, 30 early-onsets, and 22 late-onset preeclamptic and 27 control pregnant women were included into the scope of this study. Enzyme-linked immunosorbent assay procedure was used to determine the serum Lp-PLA2 and plasma Vn, t-PA antigen and PAI-1 activity levels. Serum C-reactive protein (CRP) levels were measured immunoturbidimetrically in routine clinical chemistry analyser. Results In patients with preeclampsia, Lp-PLA2, PAI-1, t-PA, CRP and blood pressures levels were increased ( p  = 0.000) and correlated with each other. Vn levels were decreased ( p  = 0.016) but not correlated with other parameters in preeclamptic patients. Conclusion We are of the opinion that increased Lp-PLA2 levels may partially contribute to endothelial dysfunction by the progression of inflammation. In addition, increased complex formation with Vn is likely to bring about the increase of PAI-1 activity in patients with preeclampsia. Moreover, increased t-PA and decreased Vn levels may also be the consequences of compensatory mechanisms against disease progression.