Ultrasensitive Allele-Specific PCR Reveals Rare Preexisting Drug-Resistant Variants and a Large Replicating Virus Population in Macaques Infected with a Simian Immunodeficiency Virus Containing Human Immunodeficiency Virus Reverse Transcriptase

• Published in: Journal of Virology Vol. 86; no. 23; pp. 12525 - 12530
• Main Authors: BOLTZ, Valerie F, AMBROSE, Zandrea, KEARNEY, Mary F, WEI SHAO, KEWALRAMANI, Vineet N, MALDARELLI, Frank, MELLORS, John W, COFFIN, John M
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.12.2012
• Subjects: Alleles; Animals; Benzoxazines - pharmacology; Benzoxazines - therapeutic use; Biological and medical sciences; Drug Resistance, Viral - genetics; Fundamental and applied biological sciences. Psychology; Genetic Diversity and Evolution; HIV Reverse Transcriptase - genetics; Macaca nemestrina; Microbiology; Miscellaneous; Mutation - drug effects; Mutation - genetics; Polymerase Chain Reaction - methods; Sequence Analysis, DNA; Simian Acquired Immunodeficiency Syndrome - drug therapy; Simian Acquired Immunodeficiency Syndrome - virology; Simian Immunodeficiency Virus - enzymology; Simian Immunodeficiency Virus - genetics; Virology; Virus; Polymerase chain reaction; Resistance; Allele; Retroviridae; Human immunodeficiency virus; Simian immunodeficiency virus; Lentivirus
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.01963-12

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