Human Adult T-Cell Leukaemia Virus Is Distinct from a Similar Isolate of Japanese Monkeys

• Published in: Journal of general virology Vol. 65; no. 12; pp. 2259 - 2264
• Main Authors: Yamamoto, Naoki, Okada, Morihisa, Hinuma, Yorio, Hirsch, Friedrich W, Chosa, Toru, Schneider, Josef, Hunsmann, Gerhard
• Format: Journal Article
• Language: English
• Published: Reading Soc General Microbiol 01.12.1984; Society for General Microbiology
• Subjects: AIDS/HIV; Animals; Antigens, Viral - analysis; Biological and medical sciences; Deltaretrovirus - analysis; Deltaretrovirus - classification; Fundamental and applied biological sciences. Psychology; Humans; Isoelectric Point; Macaca - microbiology; Microbiology; Molecular Weight; Systematics; Viral Proteins - analysis; Viral Proteins - immunology; Virology; Human origin; Taxonomy; Monkey; Animal origin; Retroviridae; Virus; Vertebrata; Mammalia; Antigenicity; Polypeptide; Primates; Differentiation; Comparative study
• ISSN: 0022-1317; 1465-2099
• DOI: 10.1099/0022-1317-65-12-2259

1 Institute for Virus Research, Kyoto University, Kyoto 606, Japan 2 Medizinische Klinik Universität Freiburg, Federal Republic of Germany and 3 Deutsches Primatenzentrum, Abteilung Virologie und Immunologie, Kellnerweg 4, D-3400 Göttingen, Federal Republic of Germany We have compared the structural polypeptides of an adult T-cell leukaemia (ATL) virus (ATLV) isolate from a Japanese patient with ATL with those of a similar virus derived from a Japanese macaque monkey. Both are distinct but related entities. Their core polypeptides p19 could not be distinguished, but p24, another core polypeptide, and their envelope glycopolypeptides differ. The human virus directs the synthesis of a single intracellular glycopolypeptide, gp68, while the macaque virus specifies two such glycopolypeptides, gp57 and gp50. Furthermore, the glycopolypeptides of both viruses are serologically distinct. Thus, these viruses represent subtypes of the ATLV family and the macaque virus is apparently not involved in human ATL. Keywords: ATLV, monkey, polypeptides Received 2 April 1984; accepted 15 August 1984.