GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility

Coronavirus disease 19 (COVID-19) is a persistent global pandemic with a very heterogeneous disease presentation ranging from a mild disease to dismal prognosis. Early detection of sensitivity and severity of COVID-19 is essential for the development of new treatments. In the present study, we measu...

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Published inFrontiers in cellular and infection microbiology Vol. 12; p. 942951
Main Authors Torrens-Mas, Margalida, Perelló-Reus, Catalina M., Trias-Ferrer, Neus, Ibargüen-González, Lesly, Crespí, Catalina, Galmes-Panades, Aina Maria, Navas-Enamorado, Cayetano, Sanchez-Polo, Andres, Piérola-Lopetegui, Javier, Masmiquel, Luis, Crespi, Lorenzo Socias, Barcelo, Carles, Gonzalez-Freire, Marta
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 22.07.2022
Subjects
ACE2
Cellular and Infection Microbiology
COVID-19
GDF5
inflammation
mutations
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Summary:Coronavirus disease 19 (COVID-19) is a persistent global pandemic with a very heterogeneous disease presentation ranging from a mild disease to dismal prognosis. Early detection of sensitivity and severity of COVID-19 is essential for the development of new treatments. In the present study, we measured the levels of circulating growth differentiation factor 15 (GDF15) and angiotensin-converting enzyme 2 (ACE2) in plasma of severity-stratified COVID-19 patients and uninfected control patients and characterized the in vitro effects and cohort frequency of ACE2 SNPs. Our results show that while circulating GDF15 and ACE2 stratify COVID-19 patients according to disease severity, ACE2 missense SNPs constitute a risk factor linked to infection susceptibility.
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Edited by: Vikas Sood, Jamia Hamdard University, India
Reviewed by: Grégory Dubourg, IHU Mediterranee Infection, France; Devin Wahl, Colorado State University, United States
These authors have contributed equally to this work and share first authorship
This article was submitted to Virus and Host, a section of the journal Frontiers in Cellular and Infection Microbiology
These authors have contributed equally to this work and share last authorship
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.942951