Nanomaterial-based aptamer biosensors for ochratoxin A detection: a review

• Published in: Analytical and bioanalytical chemistry Vol. 414; no. 9; pp. 2953 - 2969
• Main Authors: Chen, Xiujin, Gao, Dong, Sun, Fengxia, Li, Zhaozhou, Wang, Yao, Qiu, Caixia, He, Kaifeng, Wang, Jing
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2022; Springer; Springer Nature B.V
• Subjects: Analysis; Analytical Chemistry; Animal Feed; Animals; Aptamers; Biochemistry; Biosensing Techniques; Biosensors; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Feeds; Food contamination; Food Science; Laboratory Medicine; Monitoring/Environmental Analysis; Mycotoxins; Nanomaterials; Nanostructures; Nanotechnology; Ochratoxin A; Ochratoxins; Review; Surface stability; Toxicity; China; Nanomaterials; Aptasensors; Detection; Ochratoxin A
• ISSN: 1618-2642; 1618-2650
• DOI: 10.1007/s00216-022-03960-5

Ochratoxin A (OTA) is a widely distributed mycotoxin that often contaminates food, grains and animal feed. It poses a serious threat to human health because of its high toxicity and persistence. Therefore, the development of an inexpensive, highly sensitive, accurate and rapid method for OTA detection is imperative. In recent years, various nanomaterials used in the establishment of aptasensors have attracted great attention due to their large surface-to-volume ratio, good stability and facile preparation. This review summarizes the development of nanomaterial-based aptasensors for OTA determination and sample treatment over the past 5 years. The nanomaterials used in OTA aptasensors include metal, carbon, luminescent, magnetic and other nanomaterials. Finally, the limitations and future challenges in the development of nanomaterial-based OTA aptasensors are reviewed and discussed. Graphical abstract