A New, High-Efficacy, Noninvasive Transcranial Electric Stimulation Tuned to Local Neurodynamics

• Published in: The Journal of neuroscience Vol. 38; no. 3; pp. 586 - 594
• Main Authors: Cottone, Carlo, Cancelli, Andrea, Pasqualetti, Patrizio, Porcaro, Camillo, Salustri, Carlo, Tecchio, Franca
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 17.01.2018
• Subjects: Adult; Cortex (motor); EEG; Electroencephalography; Evoked Potentials, Motor - physiology; Excitability; Exploitation; Female; Humans; Low currents; Magnetic fields; Male; Middle Aged; Motor Cortex - physiology; Motor evoked potentials; Motors; Pyramidal Cells - physiology; Pyramidal tracts; Random noise; Subgroups; Transcranial Direct Current Stimulation - methods; Transcranial magnetic stimulation; Young Adult; primary motor area; transcranial electric stimulation; Functional Source Separation (FSS); personal/individual dynamics of neuronal activity; transcranial individual neurodynamics stimulation; EEG
• ISSN: 0270-6474; 1529-2401; 1529-2401
• DOI: 10.1523/JNEUROSCI.2521-16.2017

In this paper, we pose the following working hypothesis: in humans, transcranial electric stimulation (tES) with a time course that mimics the endogenous activity of its target is capable of altering the target's excitability. In our case, the target was the primary motor cortex (M1). We identified the endogenous neurodynamics of hand M1's subgroups of pyramidal neuronal pools in each of our subjects by applying Functional Source Separation (FSS) to their EEG recordings. We then tested whether the corticospinal excitability of the hand representation under the above described stimulation, which we named transcranial individual neurodynamics stimulation (tIDS), was higher than in the absence of stimulation (baseline). As a check, we compared tIDS with the most efficient noninvasive facilitatory corticospinal tES known so far, which is 20 Hz transcranial alternating current stimulation (tACS). The control conditions were as follows: (1) sham, (2) transcranial random noise stimulation (tRNS) in the same frequency range as tIDS (1–250 Hz), and (3) a low current tIDS (tIDS low ). Corticospinal excitability was measured with motor-evoked potentials under transcranial magnetic stimulation. The mean motor-evoked potential amplitude increase was 31% of the baseline during tIDS ( p < 0.001), and it was 15% during tACS ( p = 0.096). tRNS, tIDS low , and sham induced no effects. Whereas tACS did not produce an enhancement in any subject at the individual level, tIDS was successful in producing an enhancement in 8 of the 16 subjects. The results of the present proof-of-principle study showed that proper exploitation of local neurodynamics can enhance the efficacy of personalized tES. SIGNIFICANCE STATEMENT This study demonstrated that, in humans, transcranial individual neurodynamics stimulation (tIDS), which mimics the endogenous dynamics of the target neuronal pools, effectively changes the excitability of these pools. tIDS holds promise for high-efficacy personalized neuromodulations based on individual local neurodynamics.