Precise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights

Bone is a preferred site for both primary and metastasis tumors. Current diagnosis of osteopathia typically relies on noninvasive skeleton radiography technology. However, due to the limited resolution of ionizing radiation, accurate diagnosis and effective identification impairment areas are still...

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Published inFrontiers in bioengineering and biotechnology Vol. 9; p. 771153
Main Authors Cai, Qing, Li, Zuntai, Li, Baosheng, Jiang, Jiayang, Li, Xiaoyu, Meng, Weiyan, Zhu, Shoujun
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 18.11.2021
Subjects
Bioengineering and Biotechnology
bone tumor
diagnosis
near-infrared probe
osteopathia
photoX therapy
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Summary:Bone is a preferred site for both primary and metastasis tumors. Current diagnosis of osteopathia typically relies on noninvasive skeleton radiography technology. However, due to the limited resolution of ionizing radiation, accurate diagnosis and effective identification impairment areas are still lacking. Near-infrared (NIR) bioimaging, especially in the NIR-II (1000-1700 nm) regions, can provide high sensitivity and spatiotemporal resolution bioimaging compared to the conventional radiography. Thus, NIR bioimaging affords intraoperative visualization and imaging-guided surgery, aiming to overcome challenges associated with theranostics of osteopathia and bone tumors. The present review aimed to summarize the latest evidence on the use of NIR probes for the targeting bone imaging. We further highlight the recent advances in bone photoX (X presents thermal, dynamic, and immuno) therapy through NIR probes, in particular combination with other customized therapeutic agents could provide high-efficiency treatment for bone tumors.
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Reviewed by: Qingqing Miao, Soochow University, China
This article was submitted to Nanobiotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology
These authors have contributed equally to this work
Edited by: Yao Sun, Central China Normal University, China
Guosheng Song, Hunan University, China
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2021.771153