Daily Access to Sucrose Impairs Aspects of Spatial Memory Tasks Reliant on Pattern Separation and Neural Proliferation in Rats

High sugar diets reduce hippocampal neurogenesis, which is required for minimizing interference between memories, a process that involves "pattern separation." We provided rats with 2 h daily access to a sucrose solution for 28 d and assessed their performance on a spatial memory task. Suc...

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Published inLearning & memory (Cold Spring Harbor, N.Y.) Vol. 23; no. 7; pp. 386 - 390
Main Authors Reichelt, Amy C, Morris, Margaret J, Westbrook, Reginald Frederick
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.07.2016
Subjects
Animals
Biochemistry
Brain Hemisphere Functions
Brief Communication
Cell Proliferation
Control Groups
Dentate Gyrus - physiology
Dietetics
Exploratory Behavior
Interference (Learning)
Male
Maze Learning
Memory
Neurogenesis
Neurons - physiology
Novelty (Stimulus Dimension)
Rats, Sprague-Dawley
Spatial Ability
Spatial Memory
Sucrose - administration & dosage
Task Analysis
Visual Discrimination
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Summary:High sugar diets reduce hippocampal neurogenesis, which is required for minimizing interference between memories, a process that involves "pattern separation." We provided rats with 2 h daily access to a sucrose solution for 28 d and assessed their performance on a spatial memory task. Sucrose consuming rats discriminated between objects in novel and familiar locations when there was a large spatial separation between the objects, but not when the separation was smaller. Neuroproliferation markers in the dentate gyrus of the sucrose-consuming rats were reduced relative to controls. Thus, sucrose consumption impaired aspects of spatial memory and reduced hippocampal neuroproliferation.
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Present address: School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria 3083, Australia
ISSN:1072-0502
1549-5485
1549-5485
DOI:10.1101/lm.042416.116