Lymphocytes in pseudomembranes of late prosthetic joint failure

The pseudomembrane formed in association with late aseptic prosthesis failure contains a mixed giant cell and histiocytic infiltrate with variable numbers of lymphocytes. Immunolabelling with a panel of antibodies on paraffin sections was undertaken to define the nature of the lymphoid infiltrate in...

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Bibliographic Details
Published inThe Journal of pathology Vol. 166; no. 3; p. 271
Main Authors Salter, D M, Krajewski, A S, Robertson, S
Format Journal Article
LanguageEnglish
Published England 01.03.1992
Subjects
Aged
Antigens - analysis
Equipment Failure
Female
Humans
Immunologic Techniques
Joint Prosthesis
Joints - immunology
Joints - pathology
Lymphocytes - immunology
Lymphocytes - pathology
Male
Membranes - immunology
Membranes - pathology
Middle Aged
Staining and Labeling
T-Lymphocytes - immunology
T-Lymphocytes - pathology
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Summary:The pseudomembrane formed in association with late aseptic prosthesis failure contains a mixed giant cell and histiocytic infiltrate with variable numbers of lymphocytes. Immunolabelling with a panel of antibodies on paraffin sections was undertaken to define the nature of the lymphoid infiltrate in 19 cases. In all cases, the predominant lymphoid cell was a memory (CD45RO+, CD45RA-) T-cell. B-cells were rare. Tissue from patients with rheumatoid arthritis (RA) contained greater numbers of T-cells when compared with patients with osteoarthritis (OA), suggesting that the intensity of the lymphoid infiltrates reflects the underlying joint disease rather than necessarily being part of a hypersensitivity response to wear debris.
ISSN:0022-3417
DOI:10.1002/path.1711660309