Circulating T helper 9 cells and increased serum interleukin-9 levels in patients with knee osteoarthritis
Summary The purpose of this study was to examine the roles of T helper 9 (Th9) cells and the serum interleukin (IL)‐9 level in the pathogenesis of osteoarthritis (OA). The numbers of IL‐9+ CD4+ CD8− T cells, interferon (IFN)‐γ+ CD4+ CD8− T cells, IL‐4+ CD4+ CD8− T cells, and IL‐17A+ CD4+ CD8− T cell...
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Published in | Clinical and experimental pharmacology & physiology Vol. 43; no. 5; pp. 528 - 534 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Australia
Blackwell Publishing Ltd
01.05.2016
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Summary
The purpose of this study was to examine the roles of T helper 9 (Th9) cells and the serum interleukin (IL)‐9 level in the pathogenesis of osteoarthritis (OA). The numbers of IL‐9+ CD4+ CD8− T cells, interferon (IFN)‐γ+ CD4+ CD8− T cells, IL‐4+ CD4+ CD8− T cells, and IL‐17A+ CD4+ CD8− T cells in 25 OA patients and 13 healthy controls (HC) were examined by flow cytometry. The serum concentrations of IL‐9, IL‐4, IL‐17A, and IFN‐γ were also determined. The numbers of CD4+CD45RO+ T cells, Th9 cells, Th1 cells, and Th17 cells in OA patients were significantly higher than those in HCs. Furthermore, serum IL‐9, IL‐17A, and IFN‐γ levels in OA patients were higher than those in HCs. The number of Th9 cells was positively correlated with the number of Th17 cells in OA patients. Furthermore, greater numbers of Th9 cells were positively associated with elevated C‐reactive protein, and both Th9 cells and IL‐9 levels were positively correlated with the Western Ontario and McMaster Universities Osteoarthritis index in OA patients. Th9 cell numbers and IL‐9 levels are correlated with OA patient symptoms and joint functionality and may be a marker of disease activity. |
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Bibliography: | ArticleID:CEP12567 istex:7391AE620AC0894E7A7A67CC08F0B47D79CD6028 ark:/67375/WNG-4DVNKVWC-4 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0305-1870 1440-1681 |
DOI: | 10.1111/1440-1681.12567 |