Lipopolysaccharide (LPS) inhalation in healthy subjects causes bronchoalveolar neutrophilia, lymphocytosis, and fibronectin increase

Eight healthy volunteers were exposed to purified lipopolysaccharide (LPS) by controlled inhalation. Bronchoalveolar lavage (BAL) 3 hours after exposure revealed a pronounced neutrophilia, increase in lymphocytes, fibronectin concentration, and decrease in alveolar macrophage phagocytosis, as compar...

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Bibliographic Details
Published inAmerican journal of industrial medicine Vol. 25; no. 1; p. 103
Main Authors Sandström, T, Bjermer, L, Rylander, R
Format Journal Article
LanguageEnglish
Published United States 01.01.1994
Subjects
Administration, Inhalation
Adult
Bronchial Provocation Tests
Bronchoalveolar Lavage Fluid - cytology
Bronchoalveolar Lavage Fluid - immunology
Dust - adverse effects
Escherichia coli
Fibronectins - metabolism
Humans
Inflammation
Leukocyte Count
Lipopolysaccharides - adverse effects
Lymphocytosis - etiology
Lymphocytosis - physiopathology
Neutrophils - physiology
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Summary:Eight healthy volunteers were exposed to purified lipopolysaccharide (LPS) by controlled inhalation. Bronchoalveolar lavage (BAL) 3 hours after exposure revealed a pronounced neutrophilia, increase in lymphocytes, fibronectin concentration, and decrease in alveolar macrophage phagocytosis, as compared to a reference BAL.
ISSN:0271-3586
DOI:10.1002/ajim.4700250127