Telomeres, not the end of the story

Transcription in organisms as diverse as yeast and mammals is subject to chromosomal position effects that result in heritable and variegated patterns of gene expression. Two recent studies have employed a reversible protein-DNA crosslinking method to identify the structural components of heterochro...

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Bibliographic Details
Published inBioEssays Vol. 19; no. 5; p. 367
Main Authors Gotta, M, Cockell, M
Format Journal Article
LanguageEnglish
Published United States 01.05.1997
Subjects
Animals
Fungal Proteins - metabolism
Heterochromatin - metabolism
Models, Biological
Molecular Structure
Nucleosomes - metabolism
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Telomere - chemistry
Telomere - metabolism
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Summary:Transcription in organisms as diverse as yeast and mammals is subject to chromosomal position effects that result in heritable and variegated patterns of gene expression. Two recent studies have employed a reversible protein-DNA crosslinking method to identify the structural components of heterochromatin in budding yeast. The results show that a complex containing the proteins Rap1, Sir2p, Sir3p and Sir4p is physically associated with nucleosomes at telomere proximal regions, but that the repressive chromatin structure extended by Sir3p overexpression has a different composition.
ISSN:0265-9247
DOI:10.1002/bies.950190503