Social Determinants of Inter-Individual Variability and Vulnerability: The Role of Dopamine

Individuals differ in their traits and preferences, which shape their interactions, their prospects for survival and their susceptibility to diseases. These correlations are well documented, yet the neurophysiological mechanisms underlying the emergence of distinct personalities and their relation t...

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Published inFrontiers in behavioral neuroscience Vol. 16; p. 836343
Main Authors Faure, Philippe, Fayad, Sophie L, Solié, Clément, Reynolds, Lauren M
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 21.03.2022
Frontiers
Frontiers Media S.A
Subjects
Adaptation
Automation
Behavior
Dopamine
ethological analysis
Identity formation
Laboratories
Life Sciences
micro-society
Nervous system
Neuromodulation
Neurons and Cognition
Neuroscience
Personality
social behavior
Social interaction
variability – individual
vulnerability
variability – individual
ethological analysis
vulnerability
dopamine
social behavior
micro-society
variability
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Summary:Individuals differ in their traits and preferences, which shape their interactions, their prospects for survival and their susceptibility to diseases. These correlations are well documented, yet the neurophysiological mechanisms underlying the emergence of distinct personalities and their relation to vulnerability to diseases are poorly understood. Social ties, in particular, are thought to be major modulators of personality traits and psychiatric vulnerability, yet the majority of neuroscience studies are performed on rodents in socially impoverished conditions. Rodent micro-society paradigms are therefore key experimental paradigms to understand how social life generates diversity by shaping individual traits. Dopamine circuitry is implicated at the interface between social life experiences, the expression of essential traits, and the emergence of pathologies, thus proving a possible mechanism to link these three concepts at a neuromodulatory level. Evaluating inter-individual variability in automated social testing environments shows great promise for improving our understanding of the link between social life, personality, and precision psychiatry - as well as elucidating the underlying neurophysiological mechanisms.
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These authors have contributed equally to this work
Edited by: Nilay Yapici, Cornell University, United States
Reviewed by: Michael J. Sheehan, Cornell University, United States; Malavika Murugan, Emory University, United States
This article was submitted to Individual and Social Behaviors, a section of the journal Frontiers in Behavioral Neuroscience
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2022.836343