Ferritin levels and risk of heart failure—the Atherosclerosis Risk in Communities Study

• Published in: European journal of heart failure Vol. 19; no. 3; pp. 340 - 347
• Main Authors: Silvestre, Odilson M., Gonçalves, Alexandra, Nadruz Jr, Wilson, Claggett, Brian, Couper, David, Eckfeldt, John H., Pankow, James S., Anker, Stefan D., Solomon, Scott D.
• Format: Journal Article
• Language: English
• Published: Oxford, UK John Wiley & Sons, Ltd 01.03.2017
• Subjects: Biomarkers - blood; Cohort Studies; Female; Ferritin; Ferritins - blood; Heart failure; Heart Failure - blood; Heart Failure - epidemiology; Humans; Incidence; Iron - blood; Iron deficiency; Iron overload; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Prospective Studies; United States - epidemiology; Heart failure; Iron overload; Iron deficiency; Ferritin
• ISSN: 1388-9842; 1879-0844; 1879-0844
• DOI: 10.1002/ejhf.701

Aims Severe iron overload is associated with cardiac damage, while iron deficiency has been related to worse outcomes in subjects with heart failure (HF). This study investigated the relationship between ferritin, a marker of iron status, and the incidence of HF in a community‐based cohort. Methods and results We examined 1063 participants who were free of heart failure from the Atherosclerosis Risk in Communities (ARIC) Study in whom ferritin serum levels were measured at baseline (1987–1989). The participants (mean age 52.7 ± 5.5 years, 62% women), were categorized in low (<30 ng/mL; n = 153), normal (30–200 ng/mL in women and 30–300 ng/mL in men; n = 663), and high (>200 ng/mL in women and >300 ng/mL in men; n = 247) ferritin levels. Multivariable Cox proportional hazards models were used to evaluate the relationship between ferritin and incident HF. After 21 ± 4.6 years of follow‐up, HF occurred in 144 (13.5%) participants. When compared with participants with normal ferritin levels, participants with low ferritin levels had a higher risk of HF [hazard ratio (HR) = 2.24, 95% confidence interval (CI) 1.15–4.35; P = 0.02] as did those with high ferritin levels (HR = 1.81, 95% CI 1.01–3.25; P = 0.04), after adjusting for potential confounders. Notably, low ferritin levels remained associated with incident HF even after excluding subjects with anaemia (HR = 2.28, 95% CI 1.11–4.68; P = 0.03). Conclusion Derangements in iron metabolism, either low or high ferritin serum levels, were associated with higher risk of incident HF in a general population, even without concurrent anaemia. These findings suggest that iron imbalance might play a role in the development of HF.