The Catalogue of Somatic Mutations in Cancer (COSMIC)

COSMIC is currently the most comprehensive global resource for information on somatic mutations in human cancer, combining curation of the scientific literature with tumor resequencing data from the Cancer Genome Project at the Sanger Institute, U.K. Almost 4800 genes and 250000 tumors have been exa...

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Bibliographic Details
Published inCurrent protocols in human genetics Vol. Chapter 10; p. Unit 10.11
Main Authors Forbes, S A, Bhamra, G, Bamford, S, Dawson, E, Kok, C, Clements, J, Menzies, A, Teague, J W, Futreal, P A, Stratton, M R
Format Journal Article
LanguageEnglish
Published United States 01.04.2008
Subjects
Catalogs as Topic
Computer Graphics
Databases, Genetic
Genetics, Medical
Humans
Internet
Mutation
Neoplasms - classification
Neoplasms - genetics
Oncogenes
Phenotype
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Summary:COSMIC is currently the most comprehensive global resource for information on somatic mutations in human cancer, combining curation of the scientific literature with tumor resequencing data from the Cancer Genome Project at the Sanger Institute, U.K. Almost 4800 genes and 250000 tumors have been examined, resulting in over 50000 mutations available for investigation. This information can be accessed in a number of ways, the most convenient being the Web-based system which allows detailed data mining, presenting the results in easily interpretable formats. This unit describes the graphical system in detail, elaborating an example walkthrough and the many ways that the resulting information can be thoroughly investigated by combining data, respecializing the query, or viewing the results in different ways. Alternate protocols overview the available precompiled data files available for download.
ISSN:1934-8258
DOI:10.1002/0471142905.hg1011s57