Feasibility and Safety of n-Butyl Cyanoacrylate–Lipiodol–Iopamidol as an Alternative Liquid Embolic Material

Purpose To evaluate the feasibility and safety of n -butyl cyanoacrylate (NBCA)–Lipiodol–Iopamidol (NLI) as a liquid embolic material. Materials and Methods In vitro, the ratio of NLI components was adjusted and the configuration of the mixtures was assessed visually in saline. In vivo, 14 wide-neck...

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Published inCardiovascular and interventional radiology Vol. 44; no. 3; pp. 482 - 488
Main Authors Higashino, Nobuyuki, Sonomura, Tetsuo, Fukuda, Kodai, Ikoma, Akira, Okuhira, Ryuta, Ueda, Shota, Kawai, Nobuyuki
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2021
Springer Nature B.V
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Summary:Purpose To evaluate the feasibility and safety of n -butyl cyanoacrylate (NBCA)–Lipiodol–Iopamidol (NLI) as a liquid embolic material. Materials and Methods In vitro, the ratio of NLI components was adjusted and the configuration of the mixtures was assessed visually in saline. In vivo, 14 wide-necked aneurysms were created on the common carotid and external iliac arteries of four female swine. Under balloon occlusion, 12 aneurysms were embolized with NLI prepared at a NBCA–Lipidol–Iopamidol ratio of 2:3:1 (NLI231), and two were embolized with NBCA–Lipiodol (NL) prepared at a NBCA–Lipiodol ratio of 1:2 (NL12) as a trial group. We performed angiography to evaluate the effectiveness of embolization and adhesion of the embolic material to the balloons or microcatheters. Results In vitro, NLI231 (33% NBCA) was considered to be the optimal ratio for aneurysm embolization based on its configuration and stability. In vivo, embolization using NLI231 was successful and no adhesion between the embolic material and the balloons or microcatheters was observed in all 12 aneurysms. Embolization with NL12 was impossible in the other two aneurysms due to leakage and adhesion of NL. Conclusion The configuration of NLI changed at each ratio. NLI231 is a feasible and safe liquid embolic material for balloon-assisted embolization of wide-necked aneurysms in swine.
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ISSN:0174-1551
1432-086X
DOI:10.1007/s00270-020-02681-5