Codon preference reflects mistranslational constraints: a proposal
Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA's in E. coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In additi...
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| Published in | Nucleic acids research Vol. 16; no. 9; pp. 4111 - 4120 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Oxford University Press
11.05.1988
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA's in E. coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In addition, the codons are utilized, as well as arranged, to provide a hydropathically conservative amino acid as the most probable replacement resulting from a mistranslational event. |
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| AbstractList | Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA's in E. coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In addition, the codons are utilized, as well as arranged, to provide a hydropathically conservative amino acid as the most probable replacement resulting from a mistranslational event. Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA's in E. coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In addition, the codons are utilized, as well as arranged, to provide a hydropathically conservative amino acid as the most probable replacement resulting from a mistranslational event.Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA's in E. coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In addition, the codons are utilized, as well as arranged, to provide a hydropathically conservative amino acid as the most probable replacement resulting from a mistranslational event. |
| Author | McPherson, David T. |
| AuthorAffiliation | Monsanto Company, St Louis, MO 63198 |
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| Keywords | Genetic code Error Translation Codon Protein synthesis |
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| Snippet | Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed... |
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| SubjectTerms | Arginine Base Composition Biological and medical sciences Codon Escherichia coli Escherichia coli - genetics Fundamental and applied biological sciences. Psychology Lysine Molecular and cellular biology Molecular genetics Protein Biosynthesis RNA, Messenger Translation. Translation factors. Protein processing |
| Title | Codon preference reflects mistranslational constraints: a proposal |
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