Codon preference reflects mistranslational constraints: a proposal

Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA's in E. coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In additi...

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Bibliographic Details
Published inNucleic acids research Vol. 16; no. 9; pp. 4111 - 4120
Main Author McPherson, David T.
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 11.05.1988
Subjects
Arginine
Base Composition
Biological and medical sciences
Codon
Escherichia coli
Escherichia coli - genetics
Fundamental and applied biological sciences. Psychology
Lysine
Molecular and cellular biology
Molecular genetics
Protein Biosynthesis
RNA, Messenger
Translation. Translation factors. Protein processing
Genetic code
Error
Translation
Codon
Protein synthesis
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Summary:Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA's in E. coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In addition, the codons are utilized, as well as arranged, to provide a hydropathically conservative amino acid as the most probable replacement resulting from a mistranslational event.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0305-1048
1362-4962
DOI:10.1093/nar/16.9.4111