Functionalized mesoporous silica materials for controlled drug delivery
In the past decade, non-invasive and biocompatible mesoporous silica materials as efficient drug delivery systems have attracted special attention. Great progress in structure control and functionalization (magnetism and luminescence) design has been achieved for biotechnological and biomedical appl...
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| Published in | Chemical Society reviews Vol. 41; no. 9; pp. 3679 - 3698 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.01.2012
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| Subjects | |
| Online Access | Get full text |
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| Summary: | In the past decade, non-invasive and biocompatible mesoporous silica materials as efficient drug delivery systems have attracted special attention. Great progress in structure control and functionalization (magnetism and luminescence) design has been achieved for biotechnological and biomedical applications. This review highlights the most recent research progress on silica-based controlled drug delivery systems, including: (i) pure mesoporous silica sustained-release systems, (ii) magnetism and/or luminescence functionalized mesoporous silica systems which integrate targeting and tracking abilities of drug molecules, and (iii) stimuli-responsive controlled release systems which are able to respond to environmental changes, such as pH, redox potential, temperature, photoirradiation, and biomolecules. Although encouraging and potential developments have been achieved, design and mass production of novel multifunctional carriers, some practical biological application, such as biodistribution, the acute and chronic toxicities, long-term stability, circulation properties and targeting efficacy
in vivo
are still challenging.
This review highlights the most recent research progress on silica-based controlled drug delivery systems, including: (i) pure mesoporous silica sustained-release systems, (ii) magnetism and/or luminescence functionalized mesoporous silica systems and (iii) stimuli-responsive controlled release systems. |
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| Bibliography: | Jun Lin was born in Changchun, China, in 1966. He received BS and MS degrees in inorganic chemistry from Jilin University, China in 1989 and 1992, respectively, and a PhD degree (inorganic chemistry) from the Changchun Institute of Applied Chemistry in 1995. Then he went to City University of Hong Kong (1996), Institute of New Materials (Germany, 1997), Virginia Commonwealth University (USA, 1998) and University of New Orleans (USA, 1999) working as a postdoctor. He came back to China in 2000, and since then has been working as a professor in CIAC. His research interests include bulk and nanostructrued luminescent materials and multifunctional composite materials together with their applications in display, lightening and biomedical fields. Piaoping Yang is currently a Professor of chemistry in the Department of College of Material Science and Chemical Engineering at Harbin Engineering University. He received his Bachelor of Science degree at Nankai University and his PhD degree at Jilin University. After graduation he joined Prof. Jun Lin's group for postdoctoral research. His research mainly focuses on the fabrication and biomedical applications of rare earth based functional materials. Shili Gai was born in Jilin, China in 1986. She received her BS degree from Harbin Engineering University, China in 2005. She is currently pursuing her PhD under the supervision of Prof. Piaoping Yang at Harbin Engineering University. Her research focuses on the functional mesoporous silica materials used for drug delivery, including the study of the physical chemical properties and the biomedical applications of these materials. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/c2cs15308d |