Synthesis of phenanthroindolizidine alkaloids and evaluation of their antitumor activities and toxicities
We previously reported that phenanthroindolizidine alkaloid 3 and its derivatives had markedly potent in vitro cytotoxicity. However, they had low in vivo antitumor activities and high in vivo toxicities, which was a serious problem. To address this problem, new phenanthroindolizidine derivatives we...
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Published in | Bioorganic & medicinal chemistry letters Vol. 21; no. 19; pp. 5978 - 5981 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier Ltd
01.10.2011
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | We previously reported that phenanthroindolizidine alkaloid
3 and its derivatives had markedly potent in vitro cytotoxicity. However, they had low in vivo antitumor activities and high in vivo toxicities, which was a serious problem. To address this problem, new phenanthroindolizidine derivatives were synthesized and their antitumor activities and toxicities were evaluated. This study describes the relationship between the chemical structures, antitumor activities, and toxicities of these phenanthroindolizidine derivatives. Based on its properties, compound
8 was found to be the most suitable potential antitumor agent. |
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Bibliography: | http://dx.doi.org/10.1016/j.bmcl.2011.07.120 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2011.07.120 |