Pilot Study: Quantitative Photoacoustic Evaluation of Peripheral Vascular Dynamics Induced by Carfilzomib In Vivo

Carfilzomib is mainly used to treat multiple myeloma. Several side effects have been reported in patients treated with carfilzomib, especially those associated with cardiovascular events, such as hypertension, congestive heart failure, and coronary artery disease. However, the side effects, especial...

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Published inSensors (Basel, Switzerland) Vol. 21; no. 3; p. 836
Main Authors Mai, Thi Thao, Vo, Manh-Cuong, Chu, Tan-Huy, Kim, Jin Young, Kim, Chulhong, Lee, Je-Jung, Jung, Sung-Hoon, Lee, Changho
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 27.01.2021
MDPI AG
Subjects
Animals
Bortezomib - toxicity
carfilzomib
Humans
Mice
Multiple Myeloma
Oligopeptides - pharmacology
Oligopeptides - toxicity
peripheral vasculature
photoacoustic microscopy
Pilot Projects
quantitative analysis
peripheral vasculature
photoacoustic microscopy
quantitative analysis
carfilzomib
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Summary:Carfilzomib is mainly used to treat multiple myeloma. Several side effects have been reported in patients treated with carfilzomib, especially those associated with cardiovascular events, such as hypertension, congestive heart failure, and coronary artery disease. However, the side effects, especially the manifestation of cardiovascular events through capillaries, have not been fully investigated. Here, we performed a pilot experiment to monitor peripheral vascular dynamics in a mouse ear under the effects of carfilzomib using a quantitative photoacoustic vascular evaluation method. Before and after injecting the carfilzomib, bortezomib, and PBS solutions, we acquired high-resolution three-dimensional PAM data of the peripheral vasculature of the mouse ear during each experiment for 10 h. Then, the PAM maximum amplitude projection (MAP) images and five quantitative vascular parameters, i.e., photoacoustic (PA) signal, diameter, density, length fraction, and fractal dimension, were estimated. Quantitative results showed that carfilzomib induces a strong effect on the peripheral vascular system through a significant increase in all vascular parameters up to 50%, especially during the first 30 min after injection. Meanwhile, bortezomib and PBS do not have much impact on the peripheral vascular system. This pilot study verified PAM as a comprehensive method to investigate peripheral vasculature, along with the effects of carfilzomib. Therefore, we expect that PAM may be useful to predict cardiovascular events caused by carfilzomib.
ISSN:1424-8220
1424-8220
DOI:10.3390/s21030836