Drug Release Property of Lipiodol Emulsion Formed by Glass Membrane Emulsification Device for Transarterial Chemoembolization

• Published in: Cardiovascular and interventional radiology Vol. 43; no. 1; pp. 135 - 139
• Main Authors: Tanaka, Toshihiro, Nishiofuku, Hideyuki, Masada, Tetsuya, Fukuoka, Yasushi, Sato, Takeshi, Tatsumoto, Shota, Matsumoto, Takeshi, Marugami, Nagaaki, Fujihara, Mitsuteru, Kichikawa, Kimihiko
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2020; Springer Nature B.V
• Subjects: Cardiology; Chemoembolization; Chemoembolization, Therapeutic - instrumentation; Chemoembolization, Therapeutic - methods; Cocks; Droplets; Drug delivery systems; Drug Liberation; Emulsification; Emulsions; Epirubicin; Equipment Design; Ethiodized Oil - pharmacokinetics; Glass; Imaging; In Vitro Techniques; Interventional Oncology; Laboratory Investigation; Medicine; Medicine & Public Health; Nuclear Medicine; Physiochemistry; Pumping; Radiology; Size distribution; Ultrasound; Viscosity; Transarterial chemoembolization; Emulsion; Ethiodized oil
• ISSN: 0174-1551; 1432-086X
• DOI: 10.1007/s00270-019-02311-9

Purpose To evaluate physiochemical characteristics of emulsions formed by a modified emulsification device and to compare in vitro drug release properties of ethiodized oil (Lipiodol)-drug solution emulsion formed by the device and a 3-way-stopcock for conventional transarterial chemoembolization. Materials and Methods A V-shaped pumping emulsification device with a 100-μm-micropore glass membrane was developed to reduce the resistance of pumping. Epirubicin solution was mixed with Lipiodol (ratio 1:2) with pumping exchanges through the device. The percentage of water-in-oil (W/O) and droplet size distribution and viscosity were evaluated. The in vitro drug release properties were compared between using the device and a 3-way-stopcock. Results Percentage of W/O was 98.45 ± 0.03%. The median droplet size was 22.58 ± 1.70 μm, and the viscosity was 143.70 ± 12.36 cP. The released epirubicin at 0 min was 1.73 ± 1.05% in the device, whereas 41.02 ± 7.27% in a 3-way-stopcock ( P  < 0.001). The half-life of release ( t 50% ) of the device was significantly longer than that of a 3-way-stopcock (175 ± 25 vs. 8 ± 6 min, P  < 0.001). Conclusion The V-shaped emulsification device with a 100-μm-micropore glass membrane can form nearly 100% W/O emulsion with homogenous droplet sizes. Emulsion formed by the device showed a slower epirubicin release property compared with that of a 3-way-stopcock.