Predictive potential of preoperative electroencephalogram for neuropsychological change following subthalamic nucleus deep brain stimulation in Parkinson’s disease

• Published in: Acta neurochirurgica Vol. 161; no. 10; pp. 2049 - 2058
• Main Authors: Yakufujiang, Maidinamu, Higuchi, Yoshinori, Aoyagi, Kyoko, Yamamoto, Tatsuya, Abe, Midori, Okahara, Yoji, Izumi, Masaki, Nagano, Osamu, Yamanaka, Yoshitaka, Hirano, Shigeki, Shiina, Akihiro, Murata, Atsushi, Iwadate, Yasuo
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.10.2019; Springer Nature B.V
• Subjects: Brain; Cognition; Cognitive ability; Deep brain stimulation; Dyskinesia; EEG; Electrical stimuli; Electroencephalography; Functional Neurosurgery – Movement disorders; Interventional Radiology; Medicine; Medicine & Public Health; Minimally Invasive Surgery; Movement disorders; Neural coding; Neurodegenerative diseases; Neurology; Neuroradiology; Neurosurgery; Original Article - Functional Neurosurgery - Movement disorders; Parkinson's disease; Quality of life; Solitary tract nucleus; Stimulation; Subthalamic nucleus; Surgery; Surgical Orthopedics; Task complexity; Variation; Visuospatial function; Subthalamic nucleus; Deep brain stimulation; Parkinson’s disease; Neurocognitive function
• ISSN: 0001-6268; 0942-0940
• DOI: 10.1007/s00701-019-03991-5

Background Deep brain stimulation of the bilateral subthalamic nucleus (STN-DBS) improves motor fluctuation and severe dyskinesia in advanced Parkinson’s disease (PD). Effects on non-motor symptoms, such as neurocognitive side effects, can also influence the quality of life of both patients with PD and caregivers. Predictive quantitative factors associated with postoperative neurocognitive deterioration therefore warrant further attention. Here, we evaluated preoperative electroencephalogram (EEG) as a predictive marker for changes in neurocognitive functions after surgery. Methods Scalp EEG was recorded preoperatively from 17 patients with PD who underwent bilateral STN-DBS. Global relative power in the theta, alpha, and beta bands was calculated. Cognitive function was assessed with neuropsychological batteries preoperatively and 1 year after STN-DBS. Results Performance on the Symbol Search subtest of the WAIS III declined 1 year after DBS. The theta band was chosen for analysis with a 40% cutoff point for increased (≥ 40%) and decreased (< 40%) power. No significant differences between the two groups in baseline performance on most neuropsychological batteries were found, except for the Digit Symbol Coding subtest of the WAIS III. Changes in visual spatial functions were significantly different between groups. The increased theta band power group demonstrated a significant deterioration in performance on the WAIS III Matrix Reasoning subtest and the copy and immediate recall tasks of the Rey-Osterrieth complex figure test. Conclusions These findings suggest that preoperative increases in theta power are related to postoperative deterioration of visuospatial function, which indicates the predictive potential of preoperative quantitative EEG for neurocognitive changes after STN-DBS.