Risk Factors Associated with Recurrent Pregnancy Loss and Outcome of Pre-Implantation Genetic Screening of Affected Couples

Recurrent pregnancy loss (RPL) is a multifactorial disorder which affects up to 5% of couples around the world. Several factors are considered to be involved in RPL; but, the etiology remains unexplained in 35-60% of cases. The aim of this study was to assess the frequency of risk factors associated...

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Published inInternational journal of fertility & sterility Vol. 15; no. 4; pp. 269 - 274
Main Authors Fatemi, Nayeralsadat, Varkiani, Maryam, Ramezanali, Fariba, Babaabasi, Babak, Ghaheri, Azadeh, Biglari, Alireza, Totonchi, Mehdi
Format Journal Article
LanguageEnglish
Published Iran Royan Institute of Iran 01.10.2021
Royan Institute
Royan Institute (ACECR), Tehran
Subjects
array-cgh
Biology
chromosomal abnormalities
Chromosomes
Embryos
Females
Genetics
Gynecology
Health risks
Infertility
Medical screening
Miscarriage
Mutation
Ovaries
Pregnancy
recurrent pregnancy loss
Sperm
Chromosomal Abnormalities
Array-CGH
Recurrent Pregnancy Loss
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Summary:Recurrent pregnancy loss (RPL) is a multifactorial disorder which affects up to 5% of couples around the world. Several factors are considered to be involved in RPL; but, the etiology remains unexplained in 35-60% of cases. The aim of this study was to assess the frequency of risk factors associated with RPL in a group of our clinic clients, and their pre-implantation genetic screening (PGS) outcome. We designed a retrospective descriptive study among, 602 Iranian couples referred to the Royan Reproductive Clinic (Tehran-Iran) from 2006 to 2018. Their karyotyping test and PGS outcomes were analyzed. PGS had been applied by array comparative genomic hybridization (array-CGH) on embryos from these patients. Also, karyotyping test had been performed using standard cytogenetic techniques. G-banding analysis revealed a frequency of 15.61% chromosomal abnormalities in RPL couples. Also, the reciprocal translocations were more frequent (33/1204 cases) compared to the other structural abnormalities. Pregnancy rate per embryo transferred were 50% with array-CGH approach. Our findings could confirm a positive correlation between chromosomal abnormalities and RPL rate. Applying PGS for the RPL couples, leads to improvement of pregnancy success rate.
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These authors contributed equally to this work.
ISSN:2008-076X
2008-0778
DOI:10.22074/IJFS.2021.137626.1027