Glial Scar Formation Occurs in the Human Brain after Ischemic Stroke

Reactive gliosis and glial scar formation have been evidenced in the animal model of ischemic stroke, but not in human ischemic brain. Here, we have found that GFAP, ED1 and chondroitin sulphate proteoglycans (CSPG) expression were significantly increased in the cortical peri-infarct regions after i...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of medical sciences Vol. 11; no. 4; pp. 344 - 348
Main Authors Huang, Lijie, Wu, Zhe-Bao, ZhuGe, Qichuan, Zheng, WeiMing, Shao, Bei, Wang, Brian, Sun, Fen, Jin, Kunlin
Format Journal Article
LanguageEnglish
Published Australia Ivyspring International Publisher 01.01.2014
Subjects
Adult
Aged
Astrocytes - metabolism
Astrocytes - pathology
Brain - metabolism
Brain - pathology
Cicatrix - metabolism
Cicatrix - pathology
Female
Gliosis - metabolism
Gliosis - pathology
Humans
Immunohistochemistry
Male
Middle Aged
Short Research Communication
Stroke - metabolism
Stroke - pathology
reactive gliosis
glial scar
human
ischemic stroke
patients
Online AccessGet full text

Cover

More Information
Summary:Reactive gliosis and glial scar formation have been evidenced in the animal model of ischemic stroke, but not in human ischemic brain. Here, we have found that GFAP, ED1 and chondroitin sulphate proteoglycans (CSPG) expression were significantly increased in the cortical peri-infarct regions after ischemic stroke, compared with adjacent normal tissues and control subjects. Double immunolabeling showed that GFAP-positive reactive astrocytes in the peri-infarct region expressed CSPG, but showed no overlap with ED1-positive activated microglia. Our findings suggest that reactive gliosis and glial scar formation as seen in animal models of stroke are reflective of what occurs in the human brain after an ischemic injury.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interest exists.
These authors made equal contributions to this paper
ISSN:1449-1907
1449-1907
DOI:10.7150/ijms.8140