Lack of association between ADRA2B -4825 gene insertion/deletion polymorphism and migraine in Chinese Han population

• Published in: Neuroscience bulletin Vol. 26; no. 4; pp. 322 - 326
• Main Authors: Ni, Jian-Qiang, Jia, Sha-Sha, Liu, Min, Chen, Shou-Gong, Jiang, Yu-Ting, Dong, Wan-Li, Gao, Yu-Zhen
• Format: Journal Article
• Language: English
• Published: Heidelberg Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 01.08.2010
• Subjects: Adult; Anatomy; Anesthesiology; Asian Continental Ancestry Group - ethnology; Asian Continental Ancestry Group - genetics; Biomedical and Life Sciences; Biomedicine; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Human Physiology; Humans; Male; Middle Aged; Migraine Disorders - genetics; Neurology; Neurosciences; Original; Original Article; Pain Medicine; Polymorphism, Genetic - genetics; Receptors, Adrenergic, alpha-2 - genetics; Sequence Deletion - genetics; promoter of α; migraine; genetic association; 基因关联; 插入/缺失多态; α2B 肾上腺素受体基因启动子; adrenergic receptor gene; insertion/deletion polymorphism; 偏头痛
• ISSN: 1673-7067; 1995-8218; 1995-8218
• DOI: 10.1007/s12264-010-0301-0

Objective The present study aimed to estimate the association between susceptibility to migraine and the 12-nucleotide insertion/deletion (indel) polymorphism in promoter region of α 2B -adrenergic receptor gene ( ADRA2B ). Methods A case-control study was carried out in Chinese Han population, including 368 cases of migraine and 517 controls. Genomic DNA was extracted from blood samples, and DNA fragments containing the site of polymorphism were amplified by PCR. Data were adjusted for sex, age, migraine history and family history, and analyzed using a logistic regression model. Results There was no association between indel polymorphism and migraine, at either the allele or the genotype level. Conclusion These findings do not support a functional significance of ADRA2B indel polymorphism at position -4825 relative to the start codon in the far upstream region of the promoter in the present migraine subjects.