Neurocognitive and self-reported psychosocial and behavioral functioning in siblings of individuals with neurodevelopmental conditions: a study using remote self-administered testing

• Published in: Journal of clinical and experimental neuropsychology Vol. 45; no. 5; pp. 513 - 536
• Main Authors: Wolff, Brittany, Franco, Vithor Rosa, Magiati, Iliana, Pestell, Carmela F., Glasson, Emma J.
• Format: Journal Article
• Language: English
• Published: England Routledge 01.08.2023; Swets & Zeitlinger bv
• Subjects: Adolescent; Adult; Attention deficit hyperactivity disorder; Attention task; Autism; Bayes; Bayes Theorem; Bayesian analysis; Child; Cognition; Cognitive ability; Cross-Sectional Studies; Executive function; Executive Function - physiology; Female; Fetal alcohol syndrome; Humans; Male; Memory; Memory Disorders; mental health; neurocognition; Neurodevelopment; Self Report; Short term memory; Siblings; Siblings - psychology; Sleep disorders; Social interactions; Young Adult; Neurodevelopment; siblings; neurocognition; mental health; Bayes
• ISSN: 1380-3395; 1744-411X
• DOI: 10.1080/13803395.2023.2259042

NDC siblings had poorer attention and executive functioning across five experimental paradigms compared to controls. NDC siblings had poorer self-reported psychological, emotional and behavioral functioning compared to controls. Siblings of autistic persons and FASD had diffuse cognitive and self-reported functioning difficulties compared to other NDCs and controls. Baseline self-reported negative emotion reactivity and sleep problems predicted objective EF difficulties in NDC siblings after 15 months. This study compared and explored the neurocognitive profiles of siblings of persons with and without neurodevelopmental conditions (NDCs) and associations between objective test performance and self-reported psychosocial functioning. Siblings of persons with and without NDCs (64 NDC and 64 control siblings; mean age 19.88 years, range 11-27 years, 73.44% female, 75.78% White Caucasian) completed self-report questionnaires and self-administered computerized neurocognitive tests of executive functioning (EF). Using Bayesian analyses, we examined cross-sectional associations between self-reported psychosocial functioning and cognitive test performance, and predictors of EF over 15 months. NDC siblings had poorer working memory, inhibition, attention, and shifting compared to controls, as measured by experimental paradigms on the backward Corsi span, N-Back 2-back task, Stop Signal Task, Sustained Attention to Response Task, and the Wisconsin Card Sorting Test (effect size δ ranging 0.49 to 0.64). Bayesian cross-sectional networks revealed negative emotion reactivity and working memory difficulties were central to the NDC sibling network. Over 15 months, poorer EF (k low test scores) was predicted by negative emotion reactivity, sleep problems, and anxiety, over and above effects of age and subclinical autistic and ADHD traits. Siblings of autistic individuals and persons with fetal alcohol spectrum disorder had higher rates of neurocognitive and psychiatric difficulties than other NDCs and controls (Bayes factors >20). Neurocognitive difficulties were associated with transdiagnostic vulnerability to poorer wellbeing in NDC siblings. These findings demonstrate the feasibility of remote online cognitive testing and highlight the importance of individualized prevention and intervention for NDC siblings.