Lack of association between thrombosis-associated and cytokine candidate gene polymorphisms and acute rejection or vascular complications after kidney transplantation

• Published in: Nephrology, dialysis, transplantation Vol. 23; no. 1; pp. 364 - 368
• Main Authors: Alakulppi, Noora S., Kyllönen, Lauri E., Partanen, Jukka, Salmela, Kaija T., Laine, Jarmo T.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.01.2008; Oxford Publishing Limited (England)
• Subjects: Acute Disease; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Cadaver; Cytokines - genetics; Emergency and intensive care: renal failure. Dialysis management; Female; Graft Rejection - epidemiology; Graft Rejection - genetics; Humans; infarction; Infarction - epidemiology; Infarction - genetics; Intensive care medicine; Kidney Transplantation; Male; Medical sciences; Middle Aged; polymorphism; Polymorphism, Genetic; Postoperative Complications - epidemiology; rejection; Risk Factors; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; thrombosis; Thrombosis - epidemiology; Thrombosis - genetics; Vascular Diseases - epidemiology; Vascular Diseases - genetics; infarction; polymorphism; thrombosis; rejection; kidney transplantation; Kidney disease; Graft(material); Urinary system disease; Hemodialysis; Cytokine; Cardiovascular disease; Thrombosis; Vascular disease; Rejection; Extrarenal dialysis; Renal failure; Complication; Polymorphism
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/ndt/gfm528

Background. Acute rejection episodes and vascular complications are common after renal transplantation and have negative impact on the long-term patient and graft survival. We investigated whether the risks of acute rejection, thrombosis, infarction and graft loss could be predicted based on the presence of functional polymorphisms in the genes of the coagulation and endothelial inflammation cascade. Methods. The study consisted of 772 consecutive cadaver kidney transplantations from a single centre. The effects of gene polymorphisms FVL, F5R2, FII G20210A, MTHFR C677T, F13A1 V34L, TFPI P151L, PROC W380G, TNF G(-308)A, IL10 A(-592)C, IL10 A(-1082)G and IL6 C(-174)G of recipients and donors were investigated. Results. We were unable to find statistically significant associations between any of the studied polymorphisms and clinical outcomes. Conclusions. Our results indicate that high-risk renal transplant candidates cannot be identified through the routine analysis of the polymorphisms.