Antibody Binding to SARS-CoV-2 S Glycoprotein Correlates with but Does Not Predict Neutralization

• Published in: Viruses Vol. 12; no. 11; p. 1214
• Main Authors: Ding, Shilei, Laumaea, Annemarie, Benlarbi, Mehdi, Beaudoin-Bussières, Guillaume, Gasser, Romain, Medjahed, Halima, Pancera, Marie, Stamatatos, Leonidas, McGuire, Andrew T, Bazin, Renée, Finzi, Andrés
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 26.10.2020; MDPI AG
• Subjects: Animals; Antibodies, Immobilized - immunology; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Betacoronavirus - immunology; Cell Line; Communication; Convalescence; convalescent plasma; Coronavirus Infections - immunology; COVID-19; ELISA; HEK293 Cells; Humans; neutralization; Neutralization Tests; Pandemics; Pneumonia, Viral - immunology; SARS-COV-2; Spike Glycoprotein, Coronavirus - immunology; Time Factors; virus capture assay; COVID-19; SARS-COV-2; neutralization; virus capture assay; ELISA; convalescent plasma

Convalescent plasma from SARS-CoV-2 infected individuals and monoclonal antibodies were shown to potently neutralize viral and pseudoviral particles carrying the S glycoprotein. However, a non-negligent proportion of plasma samples from infected individuals, as well as S-specific monoclonal antibodi...