Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis

• Published in: Cancer letters Vol. 340; no. 1; pp. 141 - 147
• Main Authors: Shigematsu, Yasuyuki, Niwa, Tohru, Rehnberg, Emil, Toyoda, Takeshi, Yoshida, Satoshi, Mori, Akiko, Wakabayashi, Mika, Iwakura, Yoichiro, Ichinose, Masao, Kim, Yong-Joon, Ushijima, Toshikazu
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 28.10.2013
• Subjects: Animals; Apoptosis; carcinogenesis; Carcinogenesis - immunology; carcinogenicity; Cell Proliferation; epithelial cells; Epithelial Cells - immunology; Gastric cancer; gastric mucosa; Gastric Mucosa - immunology; Gastric Mucosa - pathology; Gene Expression; Helicobacter Infections - complications; Helicobacter Infections - immunology; Helicobacter pylori; Helicobacter pylori infection; Hematology, Oncology and Palliative Medicine; humans; Immunity, Cellular; Inflammation; Interleukin-1beta - physiology; Interleukin-1β; macrophages; Mice; Mice, Inbred BALB C; Mice, Knockout; neutrophils; NF-kappa B - metabolism; recruitment; stomach neoplasms; Stomach Neoplasms - immunology; Stomach Neoplasms - microbiology; Stomach Neoplasms - pathology; Transcriptional Activation; IHC; Interleukin-1β; HP; Inflammation; nuclear factor-κB; NF-κB; Helicobacter pylori infection; Helicobacter pylori; MNU; immunohistochemistry; GC; Gastric cancer; N-methyl- N-nitrosourea; N-methyl-N-nitrosourea
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2013.07.034

Highlights • Gastritis triggered by H. pylori infection was attenuated in Il1b -null mice. • Il1b -null mice showed decreased cell proliferation and increased apoptosis.