Hemodialysis for the Treatment of Pulmonary Hemorrhage From Dabigatran Overdose

• Published in: American journal of kidney diseases Vol. 62; no. 3; pp. 591 - 594
• Main Authors: Chen, Betty C., MD, Sheth, Nijal R., MD, Dadzie, Kobena A., MD, Smith, Silas W., MD, Nelson, Lewis S., MD, Hoffman, Robert S., MD, Winchester, James F., MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2013; Elsevier
• Subjects: Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antithrombins - adverse effects; Antithrombins - blood; Benzimidazoles - adverse effects; Benzimidazoles - blood; beta-Alanine - adverse effects; beta-Alanine - analogs & derivatives; beta-Alanine - blood; Biological and medical sciences; Dabigatran; dialysis; Emergency and intensive care: renal failure. Dialysis management; Hemorrhage - chemically induced; Hemorrhage - diagnosis; Hemorrhage - therapy; Humans; Intensive care medicine; Lung Diseases - chemically induced; Lung Diseases - diagnosis; Lung Diseases - therapy; Male; Medical sciences; Nephrology; Nephrology. Urinary tract diseases; overdose; Pradaxa; Renal Dialysis - methods; Treatment Outcome; dialysis; overdose; Dabigatran; Pradaxa; Nephrology; Serine endopeptidases; Enzyme; Hemodialysis; Lung; Overdosing; Enzyme inhibitor; Thrombin; Antithrombin; Respiratory system; Hemorrhage; Urology; Extrarenal dialysis; Peptidases; Treatment; Antithrombotic agent; Hydrolases; Dialysis; Overdose
• ISSN: 0272-6386; 1523-6838
• DOI: 10.1053/j.ajkd.2013.02.361

Dabigatran is an oral direct thrombin inhibitor indicated for thromboembolism prophylaxis in patients with nonvalvular atrial fibrillation. Since its approval in the United States in 2010, dabigatran-associated hemorrhages have garnered much attention because bleeding rates were higher than initially expected. Additionally, reversing anticoagulation remains challenging. Traditional modes of reversing warfarin-associated coagulopathies are ineffective in reversing anticoagulation from dabigatran. Although hemodialysis is proposed as a method to accelerate dabigatran elimination, evidence supporting its clinical utility remains unproved. We report the case of an 80-year-old man who presented with worsening hemoptysis in the setting of unintentional ingestion of excess dabigatran. Despite transfusion of 2 units of fresh frozen plasma, he continued to bleed, although his international normalized ratio improved from 8.8 to 7.2. He underwent hemodialysis, and serum dabigatran concentration decreased from 1,100 to 18 ng/mL over 4 hours, with an initial extraction ratio of 0.97 and blood clearance of 291 mL/min. Although his serum dabigatran concentration rebounded to 100 ng/mL 20 minutes after the cessation of dialysis, his bleeding stopped and he improved clinically. Hemorrhage in the setting of dabigatran anticoagulation remains a therapeutic predicament. Hemodialysis may play an adjunct role in accelerating the elimination of dabigatran in bleeding patients.