Two new aryltetralin-type lignans from Camellia oleifera husk

• Published in: Natural product research Vol. 38; no. 13; pp. 2264 - 2271
• Main Authors: Cheng, Huai-yu, Xu, Tian-qi, Hu, Ya-lin, Shu, Qing, Xu, Wei, Fan, Chun-lin, Zhou, Guang-xiong
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.07.2024; Taylor & Francis Ltd
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; antioxidant activities; Antioxidants - chemistry; Antioxidants - pharmacology; Camellia - chemistry; Camellia oleifera; Cell Line, Tumor; Chemical compounds; Cytotoxicity; Dichloromethane; Drug Screening Assays, Antitumor; ECD; Ethanol; Fruit - chemistry; fruit husk; Humans; lignan; Lignans; Lignans - chemistry; Lignans - isolation & purification; Lignans - pharmacology; Molecular Structure; Plant Extracts - chemistry; Plant Extracts - pharmacology; Quantum chemistry; Scavenging; Toxicity testing; Tumor cell lines; antioxidant activities; lignan; Camellia oleifera; fruit husk; cytotoxicity; ECD
• ISSN: 1478-6419; 1478-6427; 1478-6427
• DOI: 10.1080/14786419.2023.2172005

Two new aryltetralin-type lignans (1-2) were isolated from the dichloromethane fraction of 95% ethanol extract of Camellia oleifera fruit husk. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations of compounds 1-2 were determined by the comparison of measured ECD curves with the quantum chemical calculated ones. The new compounds were tested for their antioxidant activities and cytotoxicity against three human cancer cell lines (Huh-7, H460 and MCF-7). While compounds 1 and 2 only showed slight DPPH radical scavenging activities with the IC 50 values of 38.68 ± 5.02 and 56.62 ± 1.49 μM, respectively.