Anti-complementary constituents of Viola kunawarensis

• Published in: Natural product research Vol. 31; no. 19; pp. 2312 - 2315
• Main Authors: Wang, Hui, Cong, Wen-Li, Fu, Ze-long, Chen, Dao-Feng, Wang, Qi
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.10.2017; Taylor & Francis Ltd
• Subjects: Acetic acid; anti-complementary activity; Chemical compounds; chemical constituents; Chemical Fractionation; Chlorophyll; Complement Inactivating Agents - isolation & purification; Complement inhibitors; Coumarin; Coumarins - isolation & purification; Fractionation; Glycosides - isolation & purification; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plants, Medicinal - chemistry; Spirostans - isolation & purification; Sterols; Sterols - chemistry; Sterols - isolation & purification; Stigmasterol - analogs & derivatives; Stigmasterol - isolation & purification; Triterpenes - isolation & purification; Viola - chemistry; Viola kunawarensis; Violaceae; Violaceae; chemical constituents; anti-complementary activity; Viola kunawarensis
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2017.1297446

Activity-guided fractionation for complement inhibitors led to the isolation of 22 known compounds from Viola kunawarensis. Chemical types include six sterol compounds, three coumarin compounds, five megastigmane compounds, two triterpenoid compounds, two phenylpropanoid compounds, one chlorophyll, one amide, and two lipid compounds. Among which, two sterols (stigmasta-4-ene-3β,6β-diol and saringosterone), one amide (aurantiamide acetate) and a norsesquiterpenoid (solalyratin B) exhibited better anti-complementary effects with CH 50 values ranging from 0.02 to 0.08 mM, which are plausible candidates for developing potent anti-complementary agents.