Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals

Advanced electrode designs have made single-unit neural recordings commonplace in modern neuroscience research. However, single-unit resolution remains out of reach for the intrinsic neurons of the gastrointestinal system. Single-unit recordings of the enteric (gut) nervous system have been conducte...

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Bibliographic Details
Published inMicromachines (Basel) Vol. 9; no. 9; p. 428
Main Authors Barth, Bradley B, Huang, Hsin-I, Hammer, Gianna E, Shen, Xiling
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 25.08.2018
MDPI AG
Subjects
conscious recording
electrode implantation
enteric nervous system
in vivo electrophysiology
microelectrodes
neural interfaces
Review
neural interfaces
electrode implantation
in vivo electrophysiology
conscious recording
microelectrodes
enteric nervous system
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Summary:Advanced electrode designs have made single-unit neural recordings commonplace in modern neuroscience research. However, single-unit resolution remains out of reach for the intrinsic neurons of the gastrointestinal system. Single-unit recordings of the enteric (gut) nervous system have been conducted in anesthetized animal models and excised tissue, but there is a large physiological gap between awake and anesthetized animals, particularly for the enteric nervous system. Here, we describe the opportunity for advancing enteric neuroscience offered by single-unit recording capabilities in awake animals. We highlight the primary challenges to microelectrodes in the gastrointestinal system including structural, physiological, and signal quality challenges, and we provide design criteria recommendations for enteric microelectrodes.
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SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2072-666X
2072-666X
DOI:10.3390/mi9090428