Nitrosation of the antimicrobial drug hexetidine: Nitrosamines derived from a triamine decomposition product
Five new nitrosamines were identified as nitrosation products of N 1, N 3-bis(2-ethylhexyl)-2-methyl-1,2,3-propantriamine, a hydrolysis product usually found in preparations of the antimicrobial drug hexetidine. All nitrosamines are formed after deamination of the primary amino group by nitrosation...
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Published in | Food and chemical toxicology Vol. 31; no. 1; pp. 53 - 58 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
1993
New York, NY Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | Five new nitrosamines were identified as nitrosation products of
N
1,
N
3-bis(2-ethylhexyl)-2-methyl-1,2,3-propantriamine, a hydrolysis product usually found in preparations of the antimicrobial drug hexetidine. All nitrosamines are formed after deamination of the primary amino group by nitrosation of one of the two secondary amino groups. The propantriamine derivative is very easily nitrosatable, with total nitrosamine yields in the upper range of a comparative scale of drug nitrosatability. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0278-6915 1873-6351 |
DOI: | 10.1016/0278-6915(93)90179-3 |