Thoracic Duct Resection Has a Favorable Impact on Prognosis by Preventing Hematogenous Spread of Esophageal Cancer Cells: A Multi-institutional Analysis of 2269 Patients

• Published in: Annals of surgical oncology Vol. 28; no. 8; pp. 4402 - 4410
• Main Authors: Tanaka, Koji, Yamasaki, Makoto, Sugimura, Keijiro, Shiraishi, Osamu, Motoori, Masaaki, Hamakawa, Takuya, Takeno, Atsushi, Yamashita, Kotaro, Makino, Tomoki, Kimura, Yutaka, Miyata, Hiroshi, Hirao, Motohiro, Eguchi, Hidetoshi, Yasuda, Takushi, Yano, Masahiko, Doki, Yuichiro
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2021; Springer Nature B.V
• Subjects: Clinical trials; Cohort Studies; Esophageal cancer; Esophageal Neoplasms - pathology; Esophageal Neoplasms - surgery; Esophageal Squamous Cell Carcinoma - pathology; Esophageal Squamous Cell Carcinoma - surgery; Esophagectomy; Esophagus; Gastrointestinal Oncology; Humans; Medical prognosis; Medicine; Medicine & Public Health; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Oncology; Prognosis; Prospective Studies; Retrospective Studies; Squamous cell carcinoma; Surgery; Surgical Oncology; Survival Rate; Thoracic duct; Thoracic Duct - pathology; Tumors
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-021-09962-4

Background The impact of thoracic duct (TD) resection on prognosis is controversial. This study aimed to examine the impact of TD resection. Methods In this six-institution, matched-cohort study, 2269 consecutive patients with esophageal squamous cell carcinoma who underwent esophagectomy between 2000 and 2017 were enrolled for analysis of long-term outcomes, including overall survival (OS), disease-free survival (DFS), cause-specific survival (CSS), and recurrence patterns. Results Based on a propensity score, 642 TD-resected and 642 TD-preserved patients with all stages of disease were selected. At 5 years, the TD-resected group had an OS of 57.7%, a DFS of 50.9%, and a CSS of 62.2%. These rates were significantly higher than the corresponding rates of 48.7% ( p = 0.0078), 41.0% ( p = 0.0297), and 55.3% ( p = 0.0473) in the TD-preserved group. The OS in the TD-preserved and TD-resected groups was similar for the patients with cStage 1 or 2 ( p = 0.6265), but it was significantly higher in the TD-resected group for the patients with cStage 3 or 4 ( p = 0.0052). The incidence of total recurrence did not differ between the two groups. However, the incidence of hematogenous recurrence in the TD-resected group (19.0%) was significantly lower than in the TD-preserved group (26.2%) ( p = 0.0021). For cT4a tumors, the incidence of local recurrence in the TD-resected group (2.4%) was significantly lower than in the TD-preserved group (18.4%) ( p = 0.0183). Conclusions Performance of TD resection may help to improve prognosis, especially for patients with advanced esophageal squamous cell carcinoma, by reducing hematogenous and local recurrence. Prospective trials are needed to determine whether prophylactic TD resection has a positive impact on the prognosis of patients with esophageal cancer.