The Association between Cafestol and Cardiovascular Diseases: A Comprehensive Review

• Published in: Medicina (Kaunas, Lithuania) Vol. 60; no. 6; p. 867
• Main Authors: Hao, Wen-Rui, Cheng, Chun-Yao, Chen, Huan-Yuan, Chen, Jin-Jer, Cheng, Tzu-Hurng, Liu, Ju-Chi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.05.2024; MDPI
• Subjects: Angiogenesis; Atherosclerosis; cafestol; Cardiac arrhythmia; Cardiovascular disease; Cardiovascular Diseases; Cholesterol; Clinical trials; Coffee; Cytokines; Development and progression; Disease prevention; endothelial function; Endothelium; Epidemiology; Fibroblasts; Humans; Inflammation; lipid metabolism; Lipid Metabolism - drug effects; Lipids; Lipoproteins; Medical research; Medicine, Experimental; Metabolism; Oxidation; Oxidative stress; Physiological aspects; Physiology; Review; endothelial function; cardiovascular diseases; inflammation; lipid metabolism; cafestol
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina60060867

Cafestol, a bioactive compound found in coffee, has attracted considerable attention due to its potential impact on cardiovascular health. This review aims to comprehensively explore the association between cafestol and cardiovascular diseases. We delve into the mechanisms through which cafestol influences lipid metabolism, inflammation, and endothelial function, all of which are pivotal in cardiovascular pathophysiology. Moreover, we meticulously analyze epidemiological studies and clinical trials to elucidate the relationship between cafestol and cardiovascular outcomes. Through a critical examination of existing literature, we aim to provide insights into the potential benefits and risks associated with cafestol concerning cardiovascular health.